Dozens of firefighters were called to a blaze near the London Stadium, the home of West Ham United.
Thick black smoked billowed from the derelict building in east London on Sunday evening.
London Fire Brigade said 58 firefighters and eight fire engines were called to the fire on Wick Lane, which is close to the Queen Elizabeth Olympic Park.
Pictures and videos on Twitter showed flames and a plume of thick black smoke.
No one is believed to have been injured.