Dozens of firefighters were called to a blaze near the London Stadium, the home of West Ham United.
Thick black smoked billowed from the derelict building in east London on Sunday evening.
London Fire Brigade said 58 firefighters and eight fire engines were called to the fire on Wick Lane, which is close to the Queen Elizabeth Olympic Park.
8 fire engines & 58 firefighters have been called to a fire at a derelict building on Wick Lane in #Hackney. More info soon. pic.twitter.com/e3ZicpsoQ1
— London Fire Brigade (@LondonFire) April 1, 2018
Pictures and videos on Twitter showed flames and a plume of thick black smoke.
No one is believed to have been injured.