The building has been a care home for Island youngsters for 80 years and its closure has been attributed to a shortage of funding.
However, a deal has been reached with the Health and Social Services Department that the staff will be offered jobs in child care in the public sector for those who want to continue their careers.
The home is run by the Brig-y-Don Charitable Trust, which began its work in 1925 and became a formal association in 1939.