Randomly selected households are being contacted by letter and phone to be offered appointments at one of three testing sites across the Island.
The selected Islanders will be tested from Saturday to Tuesday. The test is a simple finger-prick test, using a single drop of blood, and results will be ready within ten minutes.
It will show how many Islanders have the antibody which prevents them from contracting coronavirus.
The anonymised results will be inputted into a database to enable Statistics Jersey to create an Islandwide picture which will be released to the public.
The sample of 500 households, which equates to about 1,500 people, will then be tested every four weeks to help better understand the spread of coronavirus and inform the government on how to ease the lockdown.
The testing programme will be extended further across the Island over the next few weeks.