Spain play Wales in a Cardiff friendly on Thursday.
Here, Press Association Sport examines the former world and European champions as they prepare for their Nations League tie against England in Seville on Monday.
Spain sacked Julen Lopetegui on the eve of the World Cup in Russia after it was announced that he would be taking over at Real Madrid at the conclusion of the tournament.
Fernando Hierro took interim charge, but Spain crashed out at the last-16 stage.
Former Barcelona boss Enrique won two LaLiga titles, three Copa del Reys and a Champions League at the Nou Camp between 2014 and 2017.
But Spain have been more direct and aggressive under Enrique, with the emphasis on creativity rather than simply possession for possession’s sake.
Enrique wants players to be fluid, to move the ball quickly and free runners into space.
Enrique’s two games in charge has seen Spain set the new Nations League alight.
Spain beat England 2-1 at Wembley with Saul Niguez and Rodrigo turning around an early deficit, while World Cup finalists Croatia were hammered 6-0 in Elche.
Players to watch
There has been something of a changing of the Spanish guard in recent times, with Iniesta and David Silva having stepped away from international football.
Isco, Dani Carvajal, Sergi Roberto, Diego Costa and Jordi Alba will all be missing against Wales and England for one reason or another.
But quality exists right through the squad – from goalkeeper David de Gea, to skipper Sergio Ramos at the back, Sergio Busquets and Thiago Alcantara in midfield and Chelsea’s Alvaro Morata up front.