Leicester return to action for the first time since the death of owner Vichai Srivaddhanaprabha as they travel to face Cardiff this weekend.
There are big games elsewhere, too, as Liverpool visit Arsenal and strugglers Huddersfield and Fulham meet on Monday night.
Here, Press Association Sport takes a look at the main talking points ahead of what promises to be an emotional weekend.
Mourning Foxes head to Cardiff
The whole of the Premier League will pay respects to Srivaddhanaprabha ahead of their respective kick-offs this weekend. The Thai businessman was one of five people to die when his helicopter crashed just moments after taking off from the King Power Stadium following last weekend’s draw with West Ham. The outpouring will be even stronger in south Wales as Leicester take to the field for the first time, with tributes planned from both teams.
Unbeaten Liverpool face in-form Arsenal
Battle at the bottom at the John Smith’s Stadium
Cherries to burst Mourinho’s bubble?
Manchester United travel to the south coast on Saturday morning knowing that a defeat would see the Red Devils drop six points adrift of Bournemouth. Mourinho’s men beat Everton last weekend but remain five points behind Arsenal in fifth and need to start the weekend in style. Bournemouth are riding the crest of a wave, however, with Eddie Howe’s side boasting more wins, fewer defeats, more goals and a stronger defence than their visitors.
Hughes could do with a spark against former side City