With Manchester City not in Premier League action this weekend there could be another shift in power in the title race as Liverpool and Tottenham do play.
Liverpool head to Manchester United in one of the division’s heavyweight clashes while there are also several important games at the foot of the table.
Here, Press Association Sport looks at five talking points ahead of the action.
Can Spurs prove they are the real deal?
Harry Kane’s return from an ankle injury could not be better timed as he is back for Tottenham’s lunchtime game at Burnley, where Spurs could steal a march in the title race. With Manchester City not in action due to the Carabao Cup final with Chelsea and Liverpool not playing until Sunday afternoon, Mauricio Pochettino’s men, currently in third, will cut the gap on those two to just two points if they can win in Lancashire. Much of the title race talk has only involved City and Liverpool, but if Spurs win and Jurgen Klopp’s side lose at Old Trafford, winning the title will be in their own hands, with visits to Anfield and the Etihad Stadium to come.
Can United dent Liverpool’s title bid?
Friday night lights in relegation battle
Both Cardiff and Fulham could boost their differing chances of beating the drop as they are both in action on Friday night. The Bluebirds, currently in 17th, could climb as high as 13th with a win over Watford at home and that will provide further solace to the unsavoury manner in which the fall-out of Emiliano Sala’s death – and disputes over his transfer fee and contract – have been played out in the public domain. Fulham’s plight is far worse than Cardiff’s and there is a sense of now-or-never as they head across the capital to West Ham, hoping for a first away win of the season. The Cottagers, who have lost five of their last six games, are eight points behind Neil Warnock’s side and surely must start winning soon if they are to avoid an instant return to the Championship.