James Milner, Roberto Firmino, Alex Oxlade-Chamberlain and Naby Keita will all leave Liverpool when their contracts expire at the end of the season.
Milner and Firmino joined the Reds in June 2015 and both played in the 2019 Champions League final victory over Tottenham.
Oxlade-Chamberlain arrived in June 2017 and Keita the following summer, with the quartet all playing their part in the Reds’ Premier League title win in the 2019-20 campaign.
A Liverpool statement said: “We can confirm Roberto Firmino, Naby Keita, James Milner and Alex Oxlade-Chamberlain will leave the club upon the expiry of their contracts this summer.
“Special acknowledgements will be paid to the quartet at Anfield, with further tributes to follow at the end of the season.”
Milner, 37, has been linked with moves to Brighton and hometown club Leeds after spending eight years at Anfield.
He has made 617 Premier League appearances in total, behind only Gareth Barry (652) and Ryan Giggs (632) on the all-time list.
The midfielder overtook Frank Lampard when making his 610th top-flight appearance early last month in a 0-0 draw at Chelsea.
Liverpool signed Milner on a free transfer from City, with whom he won two Premier League titles, an FA Cup and the League Cup during his five years at at the Etihad Stadium.
In his eight seasons with Liverpool, he won the Champions League, Premier League, FA Cup, League Cup, UEFA Super Cup and FIFA Club World Cup and made the last of his 61 appearances for England in 2016.
Firmino has scored 109 goals in all competitions for the Reds since joining from Hoffenheim, including 11 in 33 games this season.